Levocetirizine, an active isomer of Cetirizine, selectively inhibits histamine H1-receptors.
Absorption: Rapidly and extensively absorbed from the GI tract (oral); peak plasma concentration in 0.9 hr.
Distribution: Protein-binding: 91-92%.Metabolism: Via aromatic oxidation, N- and O-dealkylation and taurine conjugation.
Excretion: Via urine (85.4%), via faeces (12.9%), as metabolites and unchanged drug; 8 hr (plasma half-life).
Each film coated tablet contains
Lactation. End-stage renal disease (CrCl<10 ml/min) or hemodialysis patients.
Child 6-11 yr with renal impairment